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High levels of cholesterol in the blood (hypercholesterolemia) have been strongly linked to cardiovascular disease, as they result in atherosclerosis, otherwise known as hardening of the arteries. Although pharmaceutical companies have been treating this problem with cholesterol-lowering drugs for years, the use of negative ions to remedy this issue in a more natural way has shown promise for decades. As early as 1965, research has shown that negative ions have the ability to reduce blood cholesterol levels.